Innovative diagnostic tools for early detection of Alzheimer's disease
Year: 2014
Type: review
Abstract: Current state-of-the-art diagnostic measures of Alzheimer's disease (AD) are invasive (cerebrospinal fluid analysis), expensive (neuroimaging) and time-consuming (neuropsychological assessment) and thus have limited accessibility as frontline screening and diagnostic tools for AD. Thus, there is an increasing need for additional noninvasive and/or cost-effective tools, allowing identification of subjects in the preclinical or early clinical stages of AD who could be suitable for further cognitive evaluation and dementia diagnostics. Implementation of such tests may facilitate early and potentially more effective therapeutic and preventative strategies for AD. Before applying them in clinical practice, these tools should be examined in ongoing large clinical trials. This review will summarize and highlight the most promising screening tools including neuropsychometric, clinical, blood, and neurophysiological tests.
Source: Alzheimer s & Dementia
Institutions: German Center for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Edith Cowan University, The University of Western Australia, Australian Alzheimer’s Research Foundation, Commonwealth Scientific and Industrial Research Organisation, Australian e-Health Research Centre, University of the Basque Country, St George's, University of London, Semeion Centro Ricerche di Scienze della Comunicazione, University of Colorado Denver, Nanyang Technological University, Felix Platter-Hospital, University of North Texas Health Science Center
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1965462372