Work

Enzymatic reduction of protein-bound methionine sulfoxide.

Year: 1981

Type: article

Abstract: An enzyme that catalyzes the reduction of methionine sulfoxide residues in ribosomal protein L12 has been partially purified from Escherichia coli extracts. Methionine sulfoxide present in oxidize [Met]enkephalin is also reduced by the purified enzyme. The enzyme is different from a previously reported E. coli enzyme that catalyzes the reduction of methionine sulfoxide to methionine [Ejiri, S. I., Weissbach, H. & Brot, N. (1980) Anal. Biochem. 102, 393--398]. Extracts of rat tissues, Euglena gracilis, Tetrahymena pyriformis, HeLa cells, and spinach also can catalyze the reduction of methionine sulfoxide residues in protein.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.78.4.2155

Authors: N Brot, L Weissbach, J Werth, H Weissbach

Language: English

Topic: Redox biology and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W1965507089

FWCI: 2.47

Cites: 28

Cited by: 359

Related to: 10