Work

Penicillin Target Enzyme and the Antibiotic Binding Site

Year: 1982

Type: article

Abstract: The three-dimensional structure of a penicillin-sensitive D-alanyl-carboxypeptidase-transpeptidase has been determined by x-ray crystallography to a resolution of 2.8 angstroms. The site of binding of the beta-lactam antibiotics penicillin and cephalosporin has been located. These findings constitute direct observation of the interaction of beta-lactams with a transpeptidase enzyme and establish the feasibility of defining the molecular stereochemistry of this interaction for purposes of drug design.

Source: Science

DOI: 10.1126/science.7123246

Authors: Judith A. Kelly, Paul C. Moews, James R. Knox, Jean-Marie Frère, Jean-Marie Ghuysen

Institutions: University of Connecticut, University of Liège

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W1965606033

FWCI: 6.542

Cites: 17

Cited by: 83

Related to: 10