Tracking Drug-Resistant Streptococcus pneumoniae in Oregon: An Alternative Surveillance Method
Year: 1999
Type: article
Abstract: ResearchStreptococcus pneumoniae infections are a major cause of illness and death worldwide.Penicillin-resistant S. pneumoniae were first described in 1967 (1).Since then, the proportions of isolates resistant to penicillin and other antimicrobial agents have increased worldwide (2-5).In the United States, the combined percentage of S. pneumoniae isolates with either intermediate (MIC = 0.1-1.0µg/ml) or high (MIC 2.0 µg/ml) levels of penicillin resistance is higher than 60% in some areas (5).Strains with multidrug resistance to penicillins, macrolides, sulfonamides, and third-generation cephalosporins have been well documented (3,5-9).Despite the increasing proportion of drug-resistant S. pneumoniae and the importance of knowing the drug resistance status in determining empiric therapy, community-specific surveillance for drug-resistant S. pneumoniae is limited and its proportion is unknown in many areas (10,11).Active surveillance for invasive S. pneumoniae disease includes collection of isolates, centralized susceptibility testing, and collection of patient data (4).Although such a resource-intensive system for providing community-specific and casespecific S. pneumoniae data is beyond the means of most local and many state health agencies, hospital-specific data already exist in many areas.Many hospital laboratories perform antimicrobial susceptibility testing on S. pneumoniae isolates from sterile and nonsterile sites, and results are often tabulated for local clinicians in a summary table called an antibiogram.Antibiogram data represent invasive and noninvasive S. pneumoniae disease isolates collected from normally sterile and nonsterile sites; may include multiple isolates from the same patient; and are based on hospital laboratory antimicrobial susceptibility testing, a process that may differ between laboratories.In contrast, S. pneumoniae active surveillance data are limited to invasive disease isolates collected
Source: Emerging infectious diseases
Institution: Centers for Disease Control and Prevention
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1965685238