Work

Escherichia coli K-12 ferrous iron uptake mutants are impaired in their ability to colonize the mouse intestine

Year: 1993

Type: article

Abstract: The streptomycin-treated mouse colonization model was used to investigate the role of the Fe2+ uptake system (Feo) of Escherichia coli K12 in the colonization of the mouse intestine. Mutants impaired in the uptake of Fe2+ ions were shown to be deficient also in their colonization ability. Both enterochelin-producing and enterochelin-nonproducing Escherichia coli feo mutants were unable to colonize the mouse intestine. These results demonstrated that Fe(II) is an essential source of iron for E. coli grown in the intestine.

Source: FEMS Microbiology Letters

DOI: 10.1016/0378-1097(93)90496-o

Authors: Igor Stojiljkovic, Miloje Cobeljic, Klaus Hantke

Institutions: University of Tübingen, Military Medical Academy

Language: English

Topic: Escherichia coli research studies

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1965829665