Work

Control of 25-Hydroxycholecalciferol Metabolism by Parathyroid Glands

Year: 1972

Type: article

Abstract: Thyroparathyroidectomy of rats on a diet low in calcium reduces production of 1,25-dihydroxycholecalciferol from 25-hydroxycholecalciferol to negligible levels within 40 hr, and increases production of another metabolite, called Va. Parathyroid extract, at a dose of 20 units per day, prevents these changes. When 40 units per day of parathyroid extract is given 48 hr after thyroparathyroidectomy, 1,25-dihydroxycholecalciferol production is restored almost to control levels within 36 hr. The change brought about by parathyroid extract cannot be attributed to resulting changes in serum calcium or phosphorus concentration. It appears that the parathyroid hormone serves as a tropin for production of 1,25-dihydroxycholecalciferol, the hormonal form of vitamin D responsible for calcium mobilization from intestinal contents and bone.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.69.7.1673

Authors: M. Garabedian, M. F. Holick, H. F. Deluca, I. T. Boyle

Institution: University of Wisconsin–Madison

Language: English

Topic: Parathyroid Disorders and Treatments

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1965937833

FWCI: 54.13

Cites: 20

Cited by: 668

Related to: 10