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Epitope-optimization creates highly immunogenic alpha fetoprotein antigen to break immune tolerance and potently activates CD8 T cells to prevents autochthonous hepatocellular carcinoma

Year: 2013
Type: conference-abstract
Abstract: Meeting abstracts In this study, we investigated whether mouse alpha fetoprotein (mAFP), the shared self/tumor antigen of hepatocellular carcinoma (HCC), could be rationally engineered to create effective vaccine to break tolerance and potently activate CD8 T cells to prevent clinically-relevant
DOI: 10.1186/2051-1426-1-s1-p216
Authors: Yuan Hong, Yibing Peng, Sheng Z Guo, Junfeng Pang, Jose Guevara-patino, David H Munn, Nahid Mivechi, David Bartlett, Yukai He
Language: English
Subfield: Immunology
Open Access status: gold
Estimated APC paid: $2,490
OpenAlex ID: W1965959841
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Related to: 10