Molecular Etiologies of Schizophrenia: Are We Almost There Yet?
Year: 2011
Type: editorial
Abstract: Two articles in this issue of the Journal represent examples of what research is teaching usand not teaching us about the biological basis of schizophrenia.At best, they illustrate how discoveries in genetics and molecular neurobiology converge at the level of neural systems, and they exemplify progress via integrative approaches.At worst, they underline the very complexity of schizophrenia's nature and the failure of findings to always mesh in a simplistically pleasing way or to map against the disease as it is currently defined clinically.Both studies implicate γ-aminobutyric acid (GABA)/glutamate function, which itself has protean effects on activity of the dorsolateral prefrontal cortex and modulation of neurocircuits that have been implicated in schizophrenia (1).
Source: American Journal of Psychiatry
Author: David Goldman
Institution: National Institute on Alcohol Abuse and Alcoholism
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1966042488