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The epidemiology of published norovirus outbreaks: a review of risk factors associated with attack rate and genogroup

Year: 2012
Type: review
Abstract: The purpose of this study was to examine global epidemiological trends in human norovirus (NoV) outbreaks by transmission route and setting, and describe relationships between these characteristics, viral attack rates, and the occurrence of genogroup I (GI) or genogroup II (GII) strains in outbreaks. We analysed data from 902 reverse transcriptase-polymerase chain reaction-confirmed, human NoV outbreaks abstracted from a systematic review of articles published from 1993 to 2011 and indexed under the terms 'norovirus' and 'outbreak'. Multivariate regression analyses demonstrated that foodservice and winter outbreaks were significantly associated with higher attack rates. Foodborne and waterborne outbreaks were associated with multiple strains (GI+GII). Waterborne outbreaks were significantly associated with GI strains, while healthcare-related and winter outbreaks were associated with GII strains. These results identify important trends for epidemic NoV detection, prevention, and control.
DOI: 10.1017/s0950268812000234
Authors: J. E. MATTHEWS, B. W. DICKEY, R. D. MILLER, J. R. FELZER, B. P. DAWSON, A. S. LEE, J. J. ROCKS, J. KIEL, J. S. MONTES, C. L. MOE, J. N. S. EISENBERG, J. S. LEON
Language: English
Field: Medicine
Open Access status: bronze
Funders: U.S. Department of Education, U.S. Environmental Protection Agency, U.S. Department of Agriculture, Emory University, National Institutes of Health, National Institute of Food and Agriculture, National Institute of Allergy and Infectious Diseases
Awards: G1136092959, G4701485734, Effect of Nutrition, Immunity, and Vaccines on Pediatric Enteric Infections, G83249748, G8951879213, G965027379
OpenAlex ID: W1966065856
FWCI: 3.963
Cites: 39
Cited by: 291
Related to: 10