Phospholipid micelle encapsulated gadolinium oxide nanoparticles for imaging and gene delivery
Year: 2012
Type: article
Abstract: We encapsulated gadolinium oxide (Gd2O3) nanoparticles within phospholipid micelles as a novel low cytotoxic T1-weighted MRI imaging contrast agent (MGdNPs) that can also deliver small molecules such as DNA plasmids. MGdNPs show relatively good MRI relaxivity values, negligible cytotoxicity, excellent cellular uptake and expression of DNA plasmids in vivo. Biodistribution studies in mice show that intranasal and intraperitoneal administration of MGdNPs can effectively target specific organs.
Source: RSC Advances
DOI: 10.1039/c2ra22293k
Authors: Suraj Dixit, Mahasweta Das, Subbiah Alwarappan, Nancy L Goicochea, Mark Howell, Subhra Mohapatra, Shyam Mohapatra
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W1966080038