Year: 1999
Type: article
Abstract: MSI-78 is a peptide analog of naturally occurring magainin 2 isolated from the skin of Xenopus laevis. The peptide is known to have one of the strongest antibacterial activities in magainin 2 analogs against methicillin-resistant Staphylococcus aureus (MRSA). To find novel compounds superior to MSI-78, we have further designed, synthesizing 1,1-di(4-aminobutyl)-6-benzylindane (PM4) and 1,1-dibenzyl-6-(4-aminobutyl) indane (PM5), and tested their inhibitory ability of the growth of S. aureus. In an in vitro assay, PM4 showed the same antibacterial activity against the bacterium as MSI-78, and non-hemolytic activity against human red blood cells (RBCs) at the MIC (minimum inhibitory concentration) value, in contrast to the latter. On the other hand, PM5 showed stronger antibacterial activity than MSI-78, but being still accompanied with hemolysis at the MIC value. Otherwise, stronger decarboxylase activity for oxaloacetate was observed in PM5, rather than magainin 2 analogs or Oxaldie 1 as a control peptide, but not in PM4.
DOI: 10.1248/bpb.22.73
Authors: Naganori NUMAO, Yukiko HIROTA, Akiyo IWAHORI, Shun-ichi KIDOKORO, Masanori SASATSU, Isamu KONDO, Sachiko ITHO, Etsuko ITOH, Tadashi KATOH, Noriko SHIMOZONO, Akiko YAMAZAKI, Ken-ichi TAKAO, Susumu KOBAYASHI
Institution: Sagami Chemical Research Institute
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1966131233