Work

Regulation of Human Globin Gene Switching

Year: 1993

Type: preprint

Abstract: The β-globin multigene cluster contains five developmentally regulated genes in the order 5′-ε,γGγA,δ,β-3′. In the early stages of human development, the embryonic yolk sac is the hematopoietic tissue and expresses the ε-globin gene. This is followed by a switch to the γ-globin gene in the fetal liver and the δ- and β-globin genes in adult bone marrow (for review, see Collins and Weissman 1984).

Source: Cold Spring Harbor Symposia on Quantitative Biology

DOI: 10.1101/sqb.1993.058.01.004

Authors: F. Grosveld, M. Antoniou, M. Berry, E. de Boer, N. Dillon, J. Ellis, P. Fraser, J. Hurst, A. Imam, D. Meijer, S. Philipsen, S. Pruzina, J. Strouboulis, D. Whyatt

Institutions: National Institute for Medical Research, Erasmus University Rotterdam

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1966301788

Cites: 21

Cited by: 27

Related to: 10