Work

Pretransplant conditioning with IV busulfan (Bu) and fludarabine (Flu) as alternative to Bu and cyclophosphamide (Cy)—a safe, myeloablative regimen with high antileukemic efficacy in AML/MDS

Year: 2005

Type: article

Abstract: Background: As an alternative to Cy in combination with IV Bu as preparation for allogeneic stem cell transplantation (AlloSCT), we proposed that Flu, which does not depend on the hepatic GSH/GST pathways for its metabolism, would yield improved safety, yet retained antileukemic efficacy. We have now compared a series of patients receiving pretransplant conditioning therapy with IV Bu-Flu to that of a previous group conditioned with the IV BuCy2 regimen. Methods: Flu 40 mg/m2 IV was given once daily, each dose followed immediately by Bu 130 mg/m2 IV over 3 hr (days −6 till −3).

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2004.12.188