Work

Linking DNA Damage to Cell Cycle Checkpoints

Year: 2002

Type: article

Abstract: Cell cycle checkpoints constitute a network of signal transduction mechanisms to monitor DNA damage and replication and thereby regulate progression through the cell cycle. A series of events is triggered in cells upon DNA damage. Here we describe a framework for the understanding of the functions of the core components involved in the cell cycle response to DNA damage and the relevance to the origin of cancer.

Source: Cell Cycle

DOI: 10.4161/cc.1.3.118

Authors: Temesgen Samuel, H. Oliver Weber, Jens Oliver Funk

Institutions: Friedrich-Alexander-Universität Erlangen-Nürnberg, National Cancer Institute

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Deutsche Forschungsgemeinschaft