Work

A third T-cell receptor beta-chain variable region gene encodes reactivity to Mls-1a gene products.

Year: 1989

Type: article

Abstract: Using a quantitative RNA hybridization method, we have identified a third murine T-cell receptor beta-chain variable (V) region gene, V beta 9, that engenders recognition of Mls-1a gene products. V beta 9-expressing T cells are clonally deleted from the periphery of mice that carry the Mls-1a allele, and the fine specificity of V beta 9+ hybridomas suggests that V beta 6-, V beta 8.1-, and V beta 9-encoded T-cell receptors may recognize a similar antigenic epitope. Comparison of these three protein sequences identifies two residues that may be important in determining this recognition specificity.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.86.16.6293

Authors: M P Happ, D L Woodland, E Palmer

Institution: National Jewish Health

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: G1133533742, G1168069610, G5469191654