Work

The Mechanism of Eukaryotic Translation Initiation: New Insights and Challenges

Year: 2012

Type: preprint

Abstract: Translation initiation in eukaryotes is a highly regulated and complex stage of gene expression. It requires the action of at least 12 initiation factors, many of which are known to be the targets of regulatory pathways. Here we review our current understanding of the molecular mechanics of eukaryotic translation initiation, focusing on recent breakthroughs from in vitro and in vivo studies. We also identify important unanswered questions that will require new ideas and techniques to solve.

Source: Cold Spring Harbor Perspectives in Biology

DOI: 10.1101/cshperspect.a011544

Authors: A. G. Hinnebusch, J. R. Lorsch

Institutions: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W1966992478

Cites: 140

Cited by: 537

Related to: 10