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Carteriosulfonic Acids A−C, GSK-3β Inhibitors from a Carteriospongia sp.

Year: 2009
Type: article
Abstract: Modulators of Wnt signaling have therapeutic potential in a number of human diseases. A fractionated library from marine invertebrates was screened in a luciferase assay designed to identify modulators of Wnt signaling. A fraction from a Carteriospongia sp. sponge activated Wnt signaling and was subsequently shown to inhibit GSK-3beta, which inhibits Wnt signaling through phosphorylation of beta-catenin. Three novel natural products, carteriosulfonic acids A (1), B (2), and C (3), were identified as active constituents. The carteriosulfonic acids contain unprecedented 4,6,7,9-tetrahydroxylated decanoic acid subunits. Their structures were elucidated through analysis of NMR data and a detailed analysis of pseudo MS(3) spectra.
DOI: 10.1021/np900336f
Authors: Malcolm W. B. McCulloch, Tim S. Bugni, Gisela P. Concepcion, Gary S. Coombs, Mary Kay Harper, Simran Kaur, Gina C. Mangalindan, Misha M. Mutizwa, Charles A. Veltri, David M. Virshup, Chris M. Ireland
Language: English
Subfield: Biotechnology
Open Access status: green
Awards: G1177827534, 500 MHZ NMR SPECTROMETER, ACQUISTION OF A 300 MHZ NMR SPECTROMETER, G4231553337, VARIAN INOVA 600 MHZ NMR, G766654420, G8431829504, Antineoplastic Agents from Marine Organisms
OpenAlex ID: W1967045317
FWCI: 1.509
Cites: 19
Cited by: 47
Related to: 10