Work

Imaging a full set of optical scattering properties of biological tissue by inverse spectroscopic optical coherence tomography

Year: 2012

Type: article

Abstract: We here develop a method to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT). Tissue is modelled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. Under the first-order Born approximation, the forward model is established for ISOCT. By measuring optical quantities of tissue including the scattering power of the OCT spectrum, the reflection albedo α defined as the ratio of scattering coefficient μ(s), and the backscattering coefficient μ(b), we are able to inversely deduce the RI correlation function and image the full set of optical scattering properties.

Source: Optics Letters

DOI: 10.1364/ol.37.004443

Authors: Ji Yi, Vadim Backman

Institution: Northwestern University

Language: English

Topic: Optical Coherence Tomography Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering

Awards: EFRI-BSBA: Photonic Technique for Sensing and Understanding Subcellular Structures at Nanoscale, G6885688680, Novel Biophotonics Methodology for Colon Cancer Screening, G9000211584