Work

Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation

Year: 2014

Type: review

Abstract: The adult mammalian heart exhibits limited regenerative capacity after myocardial injury, a shortcoming that is responsible for the current lack of definitive treatments for heart failure. A search for approaches that might enhance adult heart regeneration has led to interest in the Hippo/Yap signaling pathway, a recently discovered signaling pathway that regulates cell proliferation and organ growth. Here we provide a brief overview of the Hippo/Yap pathway and its known roles in the developing and adult heart. We discuss the implications of Hippo/Yap signaling for regulation of cardiomyocyte death and regeneration.

Source: Stem Cell Research

DOI: 10.1016/j.scr.2014.04.010

Authors: Zhiqiang Lin, William T. Pu

Institutions: Boston Children's Hospital, Harvard University, Harvard Stem Cell Institute

Language: English

Topic: Congenital heart defects research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,360