Aplastic anemia: presence in human bone marrow of cells that suppress myelopoiesis.
Year: 1976
Type: article
Abstract: Bone marrow from a patient with aplastic anemia was shown by multiple criteria to have a block in early myeloid differentiation. This block was overcome in vitro by elimination of marrow lymphocytes. Furthermore, this differentiation block was transferred in vitro to normal marrow by coculturing with the patient's marrow. We suggest that some cases of aplastic anemia may be due to an immunologically based suppression of marrow cell differentiation rather than to a defect in stem cells or their necessary inductive environment.
Authors: W A Kagan, J A Ascensão, R N Pahwa, J A Hansen, G Goldstein, E B Valera, G S Incefy, M A Moore, R A Good
Institution: Memorial Sloan Kettering Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1967465816