Work

Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives

Year: 2011

Type: article

Abstract: An N-terminal and C-terminal truncated recombinant α2-6-sialyltransferase cloned from Photobacterium sp. JH-ISH-224, Psp2,6ST(15-501)-His(6), was shown to be an efficient catalyst for one-pot three-enzyme synthesis of sialyl Tn (STn) antigens and derivatives containing natural and non-natural sialic acid forms.

Source: Chemical Communications

DOI: 10.1039/c1cc12732b

Authors: Li Ding, Hai Yu, Kam Lau, Yanhong Li, Saddam Muthana, Junru Wang, Xi Chen

Institutions: University of California, Davis, Northwest A&F University

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Cancer Institute, National Institute of General Medical Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Studies of naturally occurring structurally modified carbohydrates, Oligosaccharides as antimicrobials and prebiotics, Neu5Gc and anti-Neu5Gc antibodies for detection of cancer and cancer risk

OpenAlex ID: W1967511968

FWCI: 1.653

Cites: 32

Cited by: 52

Related to: 10