Work

B-cell activation induced microRNA-21 is elevated in circulating B cells preceding the diagnosis of AIDS-related non-Hodgkin lymphomas

Year: 2012

Type: article

Study design: Observational Study

Abstract: We show that microRNA-21 is significantly elevated in peripheral B cells of HIV-infected individuals who go on to develop AIDS-related non-Hodgkin lymphoma (n=13, <3 years prior to diagnosis) when compared with HIV-negative (n=18) or HIV-positive controls (n=21) (P<0.01). Moreover, miR-21 is overexpressed in activated B cells and can be induced by interleukin 4 alone, or with CD40 or immunoglobulin M co-stimulation, and lipopolysaccharides, suggesting that miR-21 may help maintain B-cell hyperactivation, contributing to lymphomagenesis.

Source: AIDS

DOI: 10.1097/qad.0b013e3283543e0e

Authors: Dharma R. Thapa, Kishor Bhatia, Jay H. Bream, Gypsyamber D'Souza, Charles R. Rinaldo, Steven Wolinsky, Roger Detels, Otoniel Martínez-Maza

Institutions: University of California, Los Angeles, National Institutes of Health, National Cancer Institute, Johns Hopkins University, University of Pittsburgh, Northwestern University, UCLA Jonsson Comprehensive Cancer Center

Language: English

Topic: Viral-associated cancers and disorders

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Mental Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases

Awards: G1345503394, G1601898348, G227110230, Immune Dysfunction and AIDS-associated B Cell Lymphoma, G3542328388, Natural History of AIDS in Homosexual Men, G4348962262, UCLA Center for AIDS Research (CFAR), Center for HIV Identification, Prevention and Treatment Services

OpenAlex ID: W1967539215

FWCI: 2.13

Cites: 24

Cited by: 25

Related to: 10