Work

MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets

Year: 2007

Type: review

Abstract: MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci33099

Authors: Eva van Rooij, Eric N. Olson

Institution: The University of Texas Southwestern Medical Center

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Heart Association, National Institutes of Health