Work

An additional 5'-upstream exon exists in the human pleiotrophin-encoding gene

Year: 1995

Type: article

Abstract: A 2-kb 5' fragment of hPTN (human pleiotrophin-encoding) genomic DNA was sequenced. Within this region we identified a new, upstream exon (U2). Cloning and sequencing of the PCR products of cDNAs from a human melanoma cell line revealed that a 401-bp intron was spliced out between exon U2 and a previously described untranslated exon U1. Our analysis also revealed that previously reported transcription start points (tsp) of PTN are located within exon U1.

Source: Gene

DOI: 10.1016/0378-1119(94)00674-h

Authors: Shoupeng Lai, Anke M. Schulte, Anton Wellstein, Anna Tate Riegel

Institutions: Georgetown University Medical Center, Georgetown Lombardi Comprehensive Cancer Center

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,300