Work

Cell fate transitions and the replication timing decision point

Year: 2010

Type: article

Abstract: Recent findings suggest that large-scale remodeling of three dimensional (3D) chromatin architecture occurs during a brief period in early G1 phase termed the replication timing decision point (TDP). In this speculative article, I suggest that the TDP may represent an as yet unappreciated window of opportunity for extracellular cues to influence 3D architecture during stem cell fate decisions. I also describe several testable predictions of this hypothesis.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.201007125

Author: David M. Gilbert

Institution: Florida State University

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funder: National Institute of General Medical Sciences

Awards: G1505296475, G489670274, G8411566541, cis-Acting Elements Regulating Developmental Control of Replication Timing