Work

mPar6α Controls Neuronal Migration: Figure 1.

Year: 2006

Type: article

Abstract: We review studies on the polarity of developing cerebellar granule, showing that the centrosome localizes to the pole of the neuron that extrudes the nascent axon, and the Rho GTPase Cdc42 (cell division cycle 42) activates the mPar6alpha/Par3 (Par for partitioning defective) complex to coordinate actin dynamics in the growth cone. Subsequently, mPar6alpha signaling controls the migration of immature granule neurons down the Bergmann glial fibers into the internal granule cell layer in which they establish synaptic connections.

Source: Journal of Neuroscience

DOI: 10.1523/jneurosci.4060-06.2006

Authors: David J. Solecki, Eve-Ellen Govek, Mary E. Hatten

Institution: Rockefeller University

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke

Awards: Molecular Mechanisms of Granule Cell Migration, Role of Cdc42 and Par6 Polarity Complex in CNS Neuronal Migration