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Cover Picture: At Last: Erythropoietin as a Single Glycoform (Angew. Chem. Int. Ed. 46/2012)

Year: 2012

Type: article

Abstract: A glycoprotein with multiple glycosylations can be prepared by chemical synthesis as a single glycoform. In their Communication on page 11576 ff., S. J. Danishefsky et al. describe the first total synthesis of fully glycosylated erythropoietin. Glycosylation has significantly increased the stability of the protein. The fully glycosylated native protein has demonstrated substantial erythropoietic activity.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201208087

Authors: Ping Wang, Suwei Dong, John A. Brailsford, Karthik Iyer, Steven D. Townsend, Qiang Zhang, Ronald C. Hendrickson, JaeHung Shieh, Malcolm A. S. Moore, Samuel J. Danishefsky

Institutions: Memorial Sloan Kettering Cancer Center, Columbia University

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1967974735

FWCI: 0.147

Cites:

Cited by: 2

Related to: 10