Work

Characterization of a novel transcript variant of human STAU1 gene.

Year: 2008

Type: article

Abstract: Human STAU1 is one member of the family of double-stranded RNA (dsRNA)-binding proteins. It is thought to function in transporting mRNA, controlling translation and eliciting mRNA decay in neurons, and to function in infection of influenza virus and human immunodeficiency virus type 1 (HIV-1). Four transcripts coding two isoforms have been identified before. In this study, we have isolated a novel transcript of STAU1, coding a novel isoform that has six amino acids more (SFPLKQ) than isoform a. In order to examine the tissue distribution of this novel isoform, we have performed RT-PCR experiments and the analysis showed that it was highly expressed in heart, liver, kidney and pancreas.

Source: Acta Biochimica Polonica

DOI: 10.18388/abp.2008_3052

Authors: Nie Fa-Hui, Yao Hai-Feng, Qi Rui-Feng, Li Xin, Wu Cai-Bin

Institutions: Tongji University, State Key Laboratory of Pollution Control and Resource Reuse, Fudan University, East China Jiaotong University

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,750