Work

Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography

Year: 2009

Type: article

Abstract: We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level.

Source: Optics Letters

DOI: 10.1364/ol.34.003086

Authors: Vivek J. Srinivasan, Sava Sakadžić, Iwona Gorczynska, Svetlana Ruvinskaya, Weicheng Wu, James G. Fujimoto, David A. Boas

Institutions: Harvard University, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts Institute of Technology

Language: English

Topic: Optical Coherence Tomography Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Eye Institute, National Cancer Institute, National Institute of Neurological Disorders and Stroke, Air Force Office of Scientific Research

Awards: G1169916466, G1523888516, G1553028739, G1637721069, G182365684, G2213582121, G2529054258, Remodeling and recovery in the neurovascular unit, G41276363, G593967775, Optical Biopsy Using Optical Coherence Tomography, Multiscale Dynamic Measurements and Modeling of Cerebrovascular Physiology, G9000081091, G9000083564, G9000095117

OpenAlex ID: W1968097662

FWCI: 3.493

Cites: 15

Cited by: 45

Related to: 10