Work

Rethinking T cell immunity in oropharyngeal candidiasis

Year: 2009

Type: article

Abstract: The disproportionate increase in oropharyngeal candidiasis (OPC) compared with systemic and vaginal candidiasis in female patients with AIDS has been a paradox for almost three decades. New data now show that severe OPC develops in Th17-deficient mice, but not Th1-deficient mice, implicating Th17-induced effector molecules in resistance to oral disease. These findings clarify and extend our current thinking about how CD4 T cell deficiency influences susceptibility to OPC.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20090093

Authors: Liise-anne Pirofski, Arturo Casadevall

Institution: Albert Einstein College of Medicine

Language: English

Topic: HIV/AIDS oral health manifestations

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases