Year: 2006
Type: review
Abstract: HDL biosynthesisApolipoprotein production.The biosynthesis of HDL (Figure 1) is complex and involves the synthesis and secretion of the major protein components of HDL followed by the largely extracellular acquisition of lipid (phospholipids [PLs] and cholesterol) and the assembly and generation of the mature HDL particle.The major HDL apolipoproteins are apoA-I and apoA-II, and both are required for normal HDL biosynthesis.ApoA-I constitutes approximately 70% of HDL protein and is present on virtually all HDL particles (3).Thus, it is not surprising that gene deletion of Apoa1/ APOA1 results in extremely low levels of HDL-C in mice (8) and in humans (9).Atherosclerosis-prone mice lacking apoA-I develop significantly increased atherosclerosis (10).ApoA-I is synthesized in both the intestine and the liver (Figure 1), but the relative contribution of the intestine and the liver to the plasma apoA-I pool in humans remains unknown.Hepatic overex-Molecular regulation of HDL metabolism and function: implications for novel therapies
DOI: 10.1172/jci30163
Author: Daniel J. Rader
Institution: University of Pennsylvania
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: bronze
Awards: High Density Lipoprotein Metabolism Influence of Extracellular Phospholipases, MECHANISM OF PI-RELATED DYSLIPIDEMIA AND ATHEROSCLEROSIS, GENERAL CLINICAL RESEARCH CENTER, AAV Gene Therapy for Lipid Disorders, Cellular and Molecular Biology of Lipoprotein Metabolism, G6807774230, Signal Transduction in Atherosclerosis, Oxidative Modifications in Atherogenesis, HDL metabolism: Influence of extracellular lipases, G895878685
OpenAlex ID: W1968196140