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Ribonucleoside 3′‐Phosphates as Pro‐Moieties for an Orally Administered Drug

Year: 2012

Type: article

Abstract: A matter of timing: Ribonucleoside 3′-phosphates are promising pro-moieties for the timed release of orally available drugs. The pro-moiety enhances the aqueous solubility of a model drug, metronidazole, and masks its activity until release by human pancreatic ribonuclease. The rate of drug release can be tuned by changing the nucleobase.

Source: ChemMedChem

DOI: 10.1002/cmdc.201200243

Authors: Michael J. Palte, Amy K. F. Davis, Nicholas A. McGrath, Carol A. Spiegel, Ronald T. Raines

Institution: University of Wisconsin–Madison

Language: English

Topic: Drug Solubulity and Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green