Work

New Antitumor Substances, FR901463, FR901464 and FR901465. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities.

Year: 1996

Type: article

Abstract: New antitumor substances, FR901463, FR901464 and FR901465 were isolated from the culture broth of a bacterium of Pseudomonas sp. No.2663. FR901463, FR901464 and FR901465 remarkably enhanced the transcriptional activity of the promoter of SV40 DNA virus. Further, these compounds exhibited potent antitumor activities against murine and human tumor cell lines in vitro.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.49.1196

Authors: HIDENORI NAKAJIMA, BUNJI SATO, TAKASHI FUJITA, SHIGEHIRO TAKASE, HIROSHI TERANO, MASAKUNI OKUHARA

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1968393195

FWCI: 1.238

Cites: 32

Cited by: 175

Related to: 10