Inference of tumor phylogenies from genomic assays on heterogeneous samples
Year: 2011
Type: conference-paper
Abstract: Motivation: Tumorigenesis can in principle result from many combinations of mutations, but only a few roughly equivalent sequences of mutations, or "progression pathways", seem to account for most human tumors. There is hope that by cataloguing the common progression pathways, we can identify broadly useful therapeutic targets and reliable diagnostic tests to determine who will benefit from any given treatment. Phylogenetic approaches, which rely on the observation that tumors are evolving populations of cells, provide a promising way to identify robust evolutionary features across tumors. They face their own challenges, though, including the high heterogeneity of individual tumors, which makes it difficult to identify specific steps of progression.
Institution: Carnegie Mellon University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1968393646