Work

A Human Breathing Lung-on-a-Chip

Year: 2015

Type: article

Abstract: Here we describe a microphysiological system that replicates the functional unit of the living human lung. This human "breathing lung-on-a-chip" microdevice provides unique capabilities to reconstitute three-dimensional microarchitecture, dynamic mechanical activity, and integrated physiological function of the alveolar-capillary interface. We demonstrate the potential of this microengineered biomimetic model for screening environmental particulates and modeling complex human disease processes.

Source: Annals of the American Thoracic Society

DOI: 10.1513/annalsats.201410-442mg

Author: Dongeun (Dan) Huh

Institution: University of Pennsylvania

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Environmental Health Sciences