Work

A New Software Package for Predictive Gene Regulatory Network Modeling and Redesign

Year: 2013

Type: article

Abstract: The efficacy of a newly created software package for predictive modeling of developmental gene regulatory networks (GRNs) has recently been demonstrated (Peter et al., 2012 ). The program GeNeTool computes spatial gene expression patterns based on GRN interactions and thereby allows the direct comparison of predicted and observed spatial expression patterns. GeNeTool also permits in silico exploration of both cis- and trans- perturbations of GRN interactions. Here, we present this program, review briefly its major features and applications, and provide a detailed and accessible tutorial.

Source: Journal of Computational Biology

DOI: 10.1089/cmb.2012.0297

Authors: Emmanuel Faure, Isabelle S. Peter, Eric H. Davidson

Institutions: California Institute of Technology, Centre National de la Recherche Scientifique, École Polytechnique, Centre de Recherche en Épistémologie Appliquée

Language: English

Topic: Gene Regulatory Network Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

OpenAlex ID: W1968871930

FWCI: 0.746

Cites: 5

Cited by: 9

Related to: 10