Work

Are Alternative Donors Really Still “Alternative?”

Year: 2014

Type: article

Abstract: HLA-matched sibling donors (MSDs) have long been the gold standard for allogeneic blood or marrow transplantation (alloBMT), but only about 35% of patients have an HLA-matched sibling [1]. The use of HLA-matched unrelated donors (MUDs; and their accompanying donor registries) widened the donor pool, but alloBMT was still unavailable to many individuals, particularly those in need of rapid transplantation for advanced diseases or those belonging to many minority groups. Other alternative donor transplantation approaches, including umbilical cord blood transplantation (UCBT) and modern approaches to HLA-haploidentical (haplo) alloBMT, have made donors available to nearly all patients who might require alloBMT [2-5].

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2014.07.029

Authors: Christopher G. Kanakry, Leo Luznik

Institutions: Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650