Work

Atomic Force Microscope Infrared Spectroscopy of Griseofulvin Nanocrystals

Year: 2013

Type: article

Abstract: The goal of this work was to evaluate the ability of photothermal-induced resonance (PTIR) to measure the local infrared absorption spectra of crystalline organic drug nanoparticles embedded within solid matrices. Herein, the first reports of the chemical characterization of sub-100 nm organic crystals are described; infrared spectra of 90 nm griseofulvin particles were obtained, confirming the chemical resolution of PTIR beyond the diffraction limit. Additionally, particle size distributions via dynamic light scattering and PTIR image analysis were found to be similar, suggesting that the PTIR measurements are not significantly affected by inhomogeneous infrared absorptivity of this system. Thus as medical applications increasingly emphasize localized drug delivery via micro/nanoengineered structures, PTIR can be used to unambiguously chemically characterize drug formulations at these length scales.

Source: Analytical Chemistry

DOI: 10.1021/ac4025889

Authors: Aaron J. Harrison, Ecevit A. Bilgili, Stephen P. Beaudoin, Lynne S. Taylor

Institutions: Purdue University West Lafayette, New Jersey Institute of Technology

Language: English

Topic: Spectroscopy Techniques in Biomedical and Chemical Research

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, Nanjing Institute of Technology, National Institutes of Health, National Institute of General Medical Sciences

Awards: G138300334, G4176647331, Development of a new Imaging Platform for Pharmaceutical and Biomedical applicati