Work

Mechanisms and uses of hydrogen exchange

Year: 1996

Type: review

Abstract: Recent work has largely completed our understanding of the hydrogen-exchange chemistry of unstructured proteins and nucleic acids. Some of the high-energy structural fluctuations that determine the hydrogen-exchange behavior of native macromolecules have been explained; others remain elusive. A growing number of applications are exploiting hydrogen-exchange behavior to study difficult molecular systems and elicit otherwise inaccessible information on protein structure, dynamics and energetics.

Source: Current Opinion in Structural Biology

DOI: 10.1016/s0959-440x(96)80090-x

Authors: S Walter Englander, Tobin R Sosnick, Joan J Englander, Leland Mayne

Institution: University of Pennsylvania

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,360

Funder: National Institute of General Medical Sciences