Work

Antigen Localization and Migration in Immunity and Tolerance

Year: 1998

Type: review

Abstract: Survival in a hostile environment requires the ability to mount a protective immune response while avoiding a reaction of the immune system against the self. We propose that the migration and localization of antigen are the governing factors in immunologic responsiveness or unresponsiveness against infections, tumors, and self and against xenografts and allografts. This conclusion is based largely on studies of experimental viral infection13 and of the small numbers of donor leukocytes found in the blood and tissues of human and animal recipients of organ allografts (microchimerism).46 Under both circumstances, an immune response can be construed as a . . .

Source: New England Journal of Medicine

DOI: 10.1056/nejm199812243392607

Authors: Thomas E. Starzl, Rolf M. Zinkernagel

Institutions: University of Pittsburgh Medical Center, University of Zurich

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases