Year: 2008
Type: review
Abstract: Bone and the immune system are both complex tissues that respectively regulate the skeleton and the body's response to invading pathogens. It has now become clear that these organ systems often interact in their function. This is particularly true for the development of immune cells in the bone marrow and for the function of bone cells in health and disease. Because these two disciplines developed independently, investigators in each don't always fully appreciate the significance that the other system has on the function of the tissue they are studying. This review is meant to provide a broad overview of the many ways that bone and immune cells interact so that a better understanding of the role that each plays in the development and function of the other can develop. It is hoped that an appreciation of the interactions of these two organ systems will lead to better therapeutics for diseases that affect either or both.
Source: Endocrine Reviews
DOI: 10.1210/er.2007-0038
Authors: Joseph Lorenzo, Mark Horowitz, Yongwon Choi
Institutions: UConn Health, Yale University, University of Pennsylvania
Language: English
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: STUDIES ON THE REGULATION OF OSTEOCLAST PRECURSOR CELLS, REGULATION OF BONE REMODELING BY MEGAKARYOCYTES, Regulation of Osteoclast Differentiation by Pax5, Core Center. Yale Core Center for Musculoskeletal Disorders, LEUCINE-RICH REPEAT PROTEIN LRRc17 AND OSTEOCLASTS, CONTROL OF OSTEOGENESIS AND ADIPOGENESIS BY EBF
OpenAlex ID: W1969323709