Work

Biosynthesis of Heme in Vitamin E Deficiency*

Year: 1972

Type: article

Abstract: ZntroductionVitamin E,t a member of the group of fat-soluble vitamins, was discovered in the 1920s.A classical vitamin E deficiency has not been described in man, however, except in cases of defective fat absorption, in some premature infants and in some children suffering from protein-calorie maln~trition.l-~Although the tocopherols are generally considered to be biological antioxidants, Dinning and Day4 observed in 1957 that the nutritional anemia that appears in Rhesus monkeys maintained on a tocopherol-deficient diet is the result of a defect in the synthesis of heme and heme proteins.

Source: Annals of the New York Academy of Sciences

DOI: 10.1111/j.1749-6632.1972.tb27861.x

Authors: Priscilla I. Caasi, Judith Wittkop Hauswirth, P. P. Nair

Institution: Sinai Hospital

Language: English

Topic: Porphyrin Metabolism and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: bronze

Funders: National Aeronautics and Space Administration, National Institutes of Health, U.S. Public Health Service