Work

Design of Retroviral Vectors for the Insertion of Foreign Deoxyribonucleic Acid Sequences into the Avian Germ Line

Year: 1986

Type: article

Abstract: Because the available avian leukosis viral (ALV) vectors are moderately oncogenic in vivo, they are not suitable for insertion into the germ line. A significant reduction in the oncogenicity of the ALV vectors can be achieved by substituting the noncoding long terminal repeats (LTR) regions of the ALV virus with the LTR of the nononcogenic endogenous RAV-O virus. There is good evidence that the resulting RAV-O LTR vectors can be inserted into the germ line of domestic chickens and have the potential for inserting cloned sequences that can be used for poultry improvement.

Source: Poultry Science

DOI: 10.3382/ps.0651459

Authors: STEPHEN H. HUGHES, ELAINE KOSIK, ALY M. FADLY, DONALD W. SALTER, LYMAN B. CRITTENDEN

Institutions: Frederick National Laboratory for Cancer Research, National Cancer Institute, United States Department of Agriculture

Language: English

Topic: Animal Genetics and Reproduction

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,600