Synthesis of Water-Soluble Poly(α-hydroxy acids) from Living Ring-Opening Polymerization of O-Benzyl- l -serine Carboxyanhydrides
Year: 2012
Type: article
Abstract: O-benzyl-L-serine carboxyanhydrides were synthesized via diazotization of O-benzyl-L-serine with sodium nitrite in aqueous sulfuric acid solution followed by cyclization of the resulting serine-based α-hydroxy acid with phosgene. Degradable, water-soluble poly(α-hydroxy acids) bearing pendant hydroxyl groups were readily prepared under mild conditions via ring-opening polymerization of O-benzyl-L-serine carboxyanhydrides followed by removal of the benzyl group and showed excellent cell compatibility, suggesting their potential being used as novel materials in constructing drug delivery systems and as hydrogel scaffolds for tissue engineering applications.
Source: ACS Macro Letters
DOI: 10.1021/mz200165c
Authors: Yanbing Lu, Lichen Yin, Yanfeng Zhang, Zhonghai Zhang, Yunxiang Xu, Rong Tong, Jianjun Cheng
Institutions: University of Illinois Urbana-Champaign, Hunan University
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Awards: CAREER: Development of Conjugated Polymer-Drug Nanoparticulate Delivery Vehicles, G295795756, G3500118554, Training the Next Generation of Researchers in Cancer Nanotechnology at the NCI M, Developing Clinically Applicable, Cancer-Targeting Polymeric Nanoconjugates, G4778635926, Development of Helical Polypeptides for Non-Viral Gene Delivery Systems, G7392520601
OpenAlex ID: W1969395448