Work

Facilitated Substrate Transport through Membrane Proteins

Year: 2001

Type: article

Abstract: Substrate transport through the membrane protein maltoporin is facilitated by an affinity site in the channel. The analysis of the ion current fluctuations induced by penetration of the sugar into the channel yields the kinetic constants. Modification of the affinity site by replacing the aromatic residues suggests that nature has optimized the channel protein for maximum affinity at the extracellular side, as well as for an increased off-rate to eject a sugar trapped in the pore towards the periplasmic side.

Source: Physical Review Letters

DOI: 10.1103/physrevlett.86.5624

Authors: C. Hilty, M. Winterhalter

Institutions: Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale

Language: English

Topic: Nanopore and Nanochannel Transport Studies

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W1969479499

FWCI: 2.862

Cites: 17

Cited by: 47

Related to: 10