Work

A Stereoselective Synthesis of (+)-Gonyautoxin 3

Year: 2008

Type: article

Abstract: An asymmetric synthesis of the paralytic shellfish poison (PSP), (+)-gonyautoxin 3, is described. A unique, Rh-catalyzed amination reaction provides rapid access to the heteratom-rich, tricyclic core of the toxin, which is common to more than 30 related natural products. The completed route should facilitate the preparation of other naturally occurring PSPs and designed analogues thereof.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja805651g

Authors: John V. Mulcahy, J. Du Bois

Institution: Stanford University

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Amgen, GlaxoSmithKline, National Institute of Neurological Disorders and Stroke

Award: Guanidinium Toxins as Tools for Sodium Ion Channel Study