Work

VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes

Year: 2012

Type: article

Abstract: Centrioles are duplicated during S-phase to generate the two centrosomes that serve as mitotic spindle poles during mitosis. The centrosomal pool of the Mps1 kinase is important for centriole assembly, but how Mps1 is delivered to centrosomes is unknown. Here we have identified a centrosome localization domain within Mps1 and identified the mitochondrial porin VDAC3 as a protein that binds to this region of Mps1. Moreover, we show that VDAC3 is present at the mother centriole and modulates centriole assembly by recruiting Mps1 to centrosomes.

Source: Cell Cycle

DOI: 10.4161/cc.21927

Authors: Shubhra Majumder, Mark Slabodnick, Amanda Pike, Joseph Marquardt, Harold A. Fisk

Institution: The Ohio State University

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze