Work

Moxifloxacin Retains Antimycobacterial Activity in the Presence of gyrA Mutations

Year: 2014

Type: article

Abstract: Moxifloxacin-resistant Mycobacterium tuberculosis mutants were selected in vitro using different concentrations of moxifloxacin. gyrA mutations at codons 88 and 94 were associated with resistance (defined as an MIC of ≥2 μg/ml) (P < 0.0001 and P = 0.0053, respectively). Despite the presence of gyrA mutations, moxifloxacin significantly impedes bacterial growth, supporting its use for the treatment of ofloxacin-resistant M. tuberculosis.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.02583-13

Authors: Marieta McGrath, Nico C. Gey van Pittius, Frederick A. Sirgel, Paul D. Van Helden, Robin M. Warren

Institution: Stellenbosch University

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Research Foundation, Ernst and Ethel Eriksen Trust