Work

Vasodepression Induced by Acetylcholine in the Atropinized Dog

Year: 1963

Type: article

Abstract: The pressor response to acetylcholine in the atropinized dog resulted from an increase in cardiac output. The pressor response was attributed solely to the release of adrenaline from the adrenal medulla. After giving compound P-286 (N-diethylaminoethyl-N-isopentyl-N'N'-di-isopropylurea) to these dogs, acetylcholine lowered blood pressure, owing to a decrease in total peripheral resistance in the absence of an increase in cardiac output. P-286 presumably blocked the liberation of adrenaline from the adrenal glands by acetylcholine. The blood vessels contributing to the fall in peripheral resistance were not in the intestines. The fall in blood pressure was not blocked by dichloroisoprenaline and it was still present in dogs treated with reserpine. It is suggested that the fall in blood pressure was due to stimulation of ganglion cells subserving vasodilatation.

Source: British Journal of Pharmacology and Chemotherapy

DOI: 10.1111/j.1476-5381.1963.tb01495.x

Authors: R. W. GARDIER, E. A. JAMES, P. C. JOHNSON, A. B. RICHARDS, R. P. ROESCH

Institutions: Indiana University Indianapolis, Indiana University School of Medicine, The University of Texas Medical Branch at Galveston, University of Illinois Chicago

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Eli Lilly and Company