Shifting the paradigm from pathogens to pathobiome: new concepts in the light of meta-omics
Year: 2014
Type: review
Abstract: The concept of pathogenesis has evolved considerably over recent years, and the scenario "a microbe + virulence factors = disease" is probably far from reality in a number of cases. Actual pathogens have extremely broad biological diversity and are found in all major groups of microorganisms (viruses, bacteria, fungi, protozoa…). Their pathogenicity results from strong and often highly specific interactions they have with either their microbial environment, hosts and/or arthropod vectors. In this review, we explore the contribution of metagenomic approaches toward understanding pathogens within the context of microbial communities. With this broader view, we discussed the concept of "pathobiome" and the research questions that this raises.
Institutions: Bipar, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, École Nationale Vétérinaire de Toulouse, Institut National Polytechnique de Toulouse, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Animal, Santé, Territoires, Risques et Ecosystèmes, Interactions hôtes-agents pathogènes, Université de Toulouse, Institut Agro Montpellier, Centre de Biologie pour la Gestion des Populations, Institut de Recherche pour le Développement, Institut de Recherche en Horticulture et Semences, AgroParisTech, Biologie et gestion des champignons phytopathogènes, Institut National de la Recherche Agronomique, Science et Technologie du Lait et de l'Oeuf, Institut Agro Rennes-Angers, Diversité, génomes et interactions micro-organismes-insectes, Microbiologie de l’alimentation au service de la santé, Biologie et Génétique des Interactions Plante-Parasite, Biologie du Fruit et Pathologie, Université de Bordeaux
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W1970067687